• Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Wilsgaard, Tom; Averina, Maria; Sandanger, Torkjel M; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to ...
    • MercuNorth – monitoring mercury in pregnant women from the Arctic as a baseline to assess the effectiveness of the Minamata Convention 

      Adlard, Bryan; Lemire, Mélanie; Bonefeld-Jørgensen, Eva Cecilie; Long, Manhai; Ólafsdóttir, Kristín; Odland, Jon Øyvind; Rautio, Arja; Myllynen, Päivi; Sandanger, Torkjel M; Dudarev, Alexey A.; Bergdahl, Ingvar A.; Wennberg, Maria; Berner, James; Ayotte, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-03)
      Exposure to mercury (Hg) is a global concern, particularly among Arctic populations that rely on the consumption of marine mammals and fish which are the main route of Hg exposure for Arctic populations.The MercuNorth project was created to establish baseline Hg levels across several Arctic regions during the period preceding the Minamata Convention. Blood samples were collected from 669 pregnant ...
    • Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort 

      Gasull, Magda; Pumarega, José; Kiviranta, Hannu; Rantakokko, Panu; Raaschou-Nielsen, Ole; Bergdahl, Ingvar A.; Sandanger, Torkjel M; Goñi, Fernando; Cirera, Lluís; Donat-Vargas, Carolina; Alguacil, Juan; Iglesias, Mar; Tjønneland, Anne; Overvad, Kim; Mancini, Francesca Romana; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Johnson, Theron; Kühn, Tilman; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Verschuren, Monique; Vermeulen, Roel; Rylander, Charlotta; Nøst, Therese Haugdahl; Rodriguez-Barranco, Miguel; Molinuevo, Amaia; Chirlaque, Maria-Dolores; Ardanaz, Eva; Sund, Malin; Key, Tim; Ye, Weimin; Jenab, Mazda; Michaud, Dominique; Matullo, Giuseppe; Canzian, Federico; Kaaks, Rudolf; Nieters, Alexandra; Nöthlings, Ute; Jeurnink, Suzanne; Chajes, Veronique; Matejcic, Marco; Gunter, Marc; Aune, Dagfinn; Riboli, Elio; Agudo, Antoni; Gonzalez, Carlos Alberto; Weiderpass, Elisabete; Bueno-de-Mesquita, Hendrik Bastiaan; Duell, Eric J.; Vineis, Paolo; Porta, Miquel (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-23)
      <i>Background</i> - The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.<p> <p><i>Objectives</i> - First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation ...
    • Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality 

      Loftfield, Erikka; Stepien, Magdalena; Viallon, Vivian; Trijsburg, Laura; Rothwell, Joseph A.; Robinot, Nivonirina; Biessy, Carine; Bergdahl, Ingvar A.; Bodén, Stina; Schulze, Matthias B.; Bergman, Manuela; Weiderpass, Elisabete; Schmidt, Julie A.; Zamora-Ros, Raúl; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Sonestedt, Emily; Ohlsson, Bodil; Katzke, Verena; Kaaks, Rudolf; Ricceri, Fulvio; Tjønneland, Anne; Dahm, Christina C.; Sánchez, Maria-Jose; Trichopoulou, Antonia; Tumino, Rosario; Chirlaque, María-Dolores; Masala, Giovanna; Ardanaz, Eva; Vermeulen, Roel; Brennan, P; Albanes, Demetrius; Weinstein, Stephanie J.; Scalbert, Augustin; Freedman, Neal D.; Gunter, Marc; Jenab, Mazda; Sinha, Rashmi; Keski-Rahkonen, Pekka; Ferrari, Pietro (Preprint; Manuskript, 2021-05-19)
      Background - Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed because of measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.<p> <p>Methods - Untargeted metabolomics was used to identify metabolites correlated with ...
    • Plasma concentrations of persistent organic pollutants and pancreatic cancer risk 

      Porta, Miquel; Gasull, Magda; Pumarega, José; Kiviranta, Hannu; Rantakokko, Panu; Raaschou-Nielsen, Ole; Bergdahl, Ingvar A.; Sandanger, Torkjel M; Agudo, Antoni; Rylander, Charlotta; Nøst, Therese Haugdahl; Donat-Vargas, Carolina; Aune, Dagfinn; Heath, Alicia K; Cirera, Lluís; Goni-Irigoyen, Fernando; Alguacil, Juan; Giménez-Robert, Álex; Tjønneland, Anne; Sund, Malin; Overvad, Kim; Romana Mancini, Francesca; Rebours, Vinciane; Boutron-Ruault, Marie Christine; Kaaks, Rudolf; Schulze, Matthias B.; Trichopoulou, Antonia; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Vermeulen, Roel; Ramón Quirós, J; Rodríguez-Barranco, Miguel; Colorado-Yohar, Sandra M.; Chirlaque, María Dolores; Ardanaz, Eva; Wareham, Nick; Key, Tim; Johansson, Mattias; Murphy, Neil; Ferrari, Pietro; Huybrechts, Inge; Chajes, Veronique; Gonzalez, Carlos Alberto; de Mesquita, Bas Bueno; Gunter, Marc; Vainio, Elisabete Weiderpass; Riboli, Elio; Duell, Eric J; Katzke, Verena; Vineis, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)
      Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.<p> Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched ...
    • Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Wilsgaard, Tom; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Averina, Maria; Sandanger, Torkjel M; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel, 2023-03-05)
      <p><i>Background:</i> Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between ...
    • Pre- and post-diagnostic blood profiles of chlorinated persistent organic pollutants and metabolic markers in type 2 diabetes mellitus cases and controls; a pilot study 

      Berg, Vivian; Charles, Dolley; Bergdahl, Ingvar A.; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Tornevi, Andreas; Huber, Sandra; Fuskevåg, Ole Martin; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-09)
      Objective - Several risk factors for type 2 diabetes mellitus (T2DM) are also associated with blood concentrations of persistent organic pollutants (POPs), and factors related to the disease may affect POP concentrations, and subsequent associations between POPs and T2DM. The purpose of this pilot study was to investigate the change in concentrations of lipids, hormones and POPs pre- and post-diagnosis ...